Spotlight on Optics - September 2017

Femtosecond semiconductor disk lasers: a great promise for the future of nonlinear imaging

by Benjamin Willenberg

In this highlighted publication by "Spotlight on Optics", we demonstrated in several in-vivo multiphoton imaging experiments that femtosecond semiconductor disk laser can produced similar imaging results to a commonly used Ti:Sapphire laser. Such small, reliable, and cost-effective ultrafast laser sources will widen the use of multiphoton imaging in laboratories and bring in-vivo imaging to new horizons of applications.

F. F. Voigt, F. Emaury, P. Bethge, D. Waldburger, S. M. Link, S. Carta, A. van der Bourg, F. Helmchen, U. Keller, "Multiphoton in vivo imaging with a femtosecond semiconductor disk laser", Biomed. Opt. Expres, vol. 8, pp. 3213-3231, 2017

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Related news links

ETH Zurich news: weblink English versionDownloadPDF English (PDF, 339 KB), weblink German version, DownloadPDF German (PDF, 337 KB)

Collaborations and financial supports

This work was done in collaboration with the group of Prof. Fritjof Helmchen at the University of Zurich (external pageweblink).

The project was financially supported by Nano-tera.ch within the MIXSEL2 project (external pageweblink).

These semiconductor disk lasers are now further developed toward commercialization in the field of biomedical imaging by Dr. Florian Emaury, who is supported by a Bridge Proof-of-Concept grant (external pageweblinkETH news).

Contact person: Dr. Florian Emaury

Multiphoton imaging in a Drosophila larva using an ultrafast semiconductor disk laser
A) Multiphoton imaging in a Drosophila larva using the ultrafast semiconductor disk laser. Red channel: Fluorescence from mKate2, Green channel: SHG signal. The SHG signal is predominantly originating from sarcomeres in the muscles. B) Image of the sarcomeres at higher zoom showing the characteristic double-band structure. (Figure taken form original publication.)
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